DIM and other plant indoles are found in all cruciferous vegetables. Scott Connelly, MD.ĭiindolylmethane, or DIM for short, is a plant indole-a plant compound with health- promoting properties. The majority of this article is information obtained from the book “All About DIM” by Michael A. Information contained in this Product Technical Sheet is for educational purposes only and is not intended to provide personal medical advice. On the other hand, 2-hydroxy estrogens have been shown to be powerfully protective of those same tissues. Obesity is also associated with unfavorable estrogen metabolites.
Research has shown 4-hydroxy and 16-hydroxy estrogens to be powerful growth and inflammation promoters, with direct connections to uncontrolled cell proliferation, especially in estrogen-sensitive tissues such as the uterus, cervix, and prostate. Estrogen is metabolized into several different post-estrogen hormones, namely 2-hydroxy, 4-hydroxy and 16-hydroxy estrogens. Due to its potent capability to bind to estrogen receptors, the unhealthy forms of estrogen have the potential to contribute to the Metabolic Syndrome. Specifically Benefits Estrogen MetabolismĮstrogen is an essential hormone present in women and men.This activity assists the body in eliminating poorly soluble, pro-inflammatory environmental chemicals helping to reduce an important source of inflammation. Taking supplemental DIM supports the metabolic pathway for DIM, which helps to stimulate the metabolism of other poorly soluble substances. In recent research, BioDIM® was shown to specifically inhibit the production and release of inflammation promoting cytokines from macrophages. Known as the ‘conductors’ of the immune response, macrophages produce and secrete an array of pro-inflammatory hormones and cytokines, which may contribute to the Metabolic Syndrome and promote atherogenesis. Macrophages accumulate in fat deposits, particularly intra-abdominal fat, as well as other sites of inflammation. Recent research shows that even at low doses, BioDIM* suppresses the inflammatory response produced by activated macrophages, present in all tissues in blood. Micro-encapsulated DIM has shown specific modulatory activity of inflammatory receptors and mediators, as well as supporting the antioxidant enzymes within cells. Other environmental chemicals, ranging from plastics to pesticides, tobacco, hydrocarbons, and petrochemicals, can also contribute to chronic inflammation. adults who are otherwise considered healthy. New population studies show that blood levels of organo-chlorine pesticides and polychlorinated biphenyls (PCBs) are significantly associated with elevated fasting glucose and greater waist circumferences in U.S. The accumulation of visceral fat has been attributed to “high-glycemic” processed starches and sugars, trans-fats, and lack of exercise new research shows that exposure to environmental pollutants can also cause systemic inflammation. Evidence shows that low levels of generalized inflammation and cellular, oxidative stress are linked to the insulin resistance and weight gain associated with the Metabolic Syndrome. The epidemic of “Metabolic Syndrome” is now recognized as a manifestation of abdominal obesity and hyperlipemias with elevated serum cholesterol, and increased blood sugar levels.
Maintaining Healthy Cells by Reducing Inflammation
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Activating these pathways encourages remarkable weight loss and hormonal balance, plus DIM provides many other benefits towards healthy aging. Studies have shown that DIM promotes healthy estrogen metabolism in both men and women. When absorbed, DIM promotes estrogen metabolism to produce healthy and protective 2-hydroxy estrogens and minimizes the activity of pro-inflammatory enzymes, thereby reducing cellular inflammation. BioDIM” is a patented, bioavailability-enhanced form of DIM that provides substantially greater absorption than ordinary DIM. To be absorbed, pure DIM must be micro-encapsulated in order to significantly increase the gastrointestinal absorption of DIM. The medical division of Vitamin Research ProductsĭIM (Diindolylmethane) is a natural antioxidant and phytonutrient found in cruciferous vegetables research has shown it to have powerful anti-inflammatory activity. This is the Technical Data Sheet directly from the manufacturer of BioDim:
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